Background

Oral lichen planus (OLP) is a T-cell-mediated inflammatory disease with a risk of malignant transformation. Although the etiology of OLP is still uncertain, growing evidence suggests that oral microbiota, antigen-specific, and non-specific mechanisms are involved in the pathogenesis of OLP. Antigen-specific mechanisms include antigen presentation, T-cell activation, nuclear factor-kappa B signaling pathway, and cytokine secretion, while non-specific mechanisms consist of matrix metalloproteinases (MMP)-9 upregulation, psychological pressure, oxidative damage, aberrant expression of microRNAs (miRNAs), and autophagy. Till now, there is no cure for OLP, and the main purpose of OLP therapy is symptomatic control.

Finding

Seafood and its derivative omega-3 polyunsaturated fatty acids (n-3 PUFAs) can suppress antigen presentation, T-cell activation, and nuclear factor-kappa B signaling pathway, modulate the overexpressed inflammatory cytokines, inhibit the expression of MMP-9, as well as regulate the expression of miRNAs and autophagy. And they are possible agents for ameliorating psychological disorder and oxidative damage. Moreover, n-3 PUFAs supplementation has a beneficial effect on preventing tumorigenesis.

Conclusion

n-3 PUFAs consumption may provide a non-toxic, inexpensive administration for OLP.

中文翻译：

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Omega-3 多不饱和脂肪酸：一种治疗口腔扁平苔藓的有前途的方法。

背景

口腔扁平苔藓 (OLP) 是一种 T 细胞介导的炎症性疾病，具有恶变风险。尽管 OLP 的病因尚不确定，但越来越多的证据表明口腔微生物群、抗原特异性和非特异性机制参与 OLP 的发病机制。抗原特异性机制包括抗原呈递、T 细胞活化、核因子-κB 信号通路和细胞因子分泌，而非特异性机制包括基质金属蛋白酶 (MMP)-9 上调、心理压力、氧化损伤、 microRNA (miRNA) 和自噬。目前，OLP 尚无治愈方法，OLP 治疗的主要目的是对症控制。

寻找

海鲜及其衍生物 omega-3 多不饱和脂肪酸 ( n -3 PUFA) 可以抑制抗原呈递、T 细胞活化和核因子-κB 信号通路，调节过度表达的炎性细胞因子，抑制 MMP-9 的表达，如以及调节 miRNA 的表达和自噬。它们可能是改善心理障碍和氧化损伤的药物。此外，n -3 PUFAs 补充剂对预防肿瘤发生具有有益作用。

结论

n -3 PUFAs 消耗可能为 OLP 提供无毒、廉价的管理。