A cancer diagnosis is suggested to be associated with changes in dietary and lifestyle habits. Whether this applies to persons with familial cancer, such as Lynch syndrome (LS) is unknown. We investigated whether a colorectal neoplasm (CRN) diagnosis in persons with LS is associated with changes in dietary and lifestyle habits over time. We used data of confirmed LS mutation carriers from the GEOLynch study, a prospective cohort study. Information on dietary intake and lifestyle habits was collected with a validated semi-quantitative food frequency questionnaire and a general questionnaire administered at baseline (2006–2008) and follow-up (2012–2017). Participants’ medical records were used to identify CRN diagnoses. Changes in dietary and lifestyle habits in the CRN and the no-CRN group were compared using multivariable linear regression models for continuous variables and cross-tables with percentage change at follow-up compared with baseline for categorical variables. Of the 324 included participants, 146 developed a CRN (CRN group) between baseline and follow-up, while 178 did not (no-CRN group). Smoking cessation was more often reported in the CRN than in the no-CRN group (41.4% vs. 35.0%). There were no differences in changes of energy intake, alcohol, red meat, processed meat, dairy, fruit, vegetables and dietary fiber consumption, BMI, physical activity and NSAID use. Apart from a potentially higher likelihood of smoking cessation, we found little evidence that a CRN diagnosis is associated with changes in lifestyle habits in persons with LS.

癌症诊断被认为与饮食和生活习惯的改变有关。这是否适用于患有家族性癌症（例如林奇综合征（LS））的人尚不清楚。我们调查了 LS 患者的结直肠肿瘤 (CRN) 诊断是否与饮食和生活习惯随时间的变化有关。我们使用了 GEOLynch 研究（一项前瞻性队列研究）中已确认的 LS 突变携带者的数据。通过经过验证的半定量食物频率调查问卷和基线（2006-2008）和随访（2012-2017）时进行的一般调查问卷收集有关饮食摄入和生活习惯的信息。参与者的医疗记录用于识别 CRN 诊断。使用连续变量的多变量线性回归模型和交叉表比较 CRN 组和无 CRN 组饮食和生活习惯的变化，并使用随访时与分类变量基线相比的百分比变化。在 324 名参与者中，146 名在基线和随访期间建立了 CRN（CRN 组），而 178 名则没有（无 CRN 组）。CRN 组比非 CRN 组更常报告戒烟（41.4% vs. 35.0%）。能量摄入、酒精、红肉、加工肉类、乳制品、水果、蔬菜和膳食纤维消耗、体重指数、体力活动和非甾体抗炎药的使用没有差异。除了戒烟的可能性较高之外，我们几乎没有发现任何证据表明 CRN 诊断与 LS 患者的生活习惯改变有关。