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Prolonged Hyperglycemia Reduces Elasticity of Type II Diabetic Rat Bone.
Calcified Tissue International ( IF 4.2 ) Pub Date : 2020-08-07 , DOI: 10.1007/s00223-020-00733-z
Hirokazu Yasui 1 , Keita Yano 1 , Yuki Kuzuhara 2 , Masaya Ikegawa 2 , Mami Matsukawa 1
Affiliation  

An increase in bone fracture risk has been reported in patients with diabetes. To evaluate an early effect of glucose intolerance on bone homeostasis, we have characterized bones from spontaneously diabetic torii (SDT) rats, an animal model of type 2 diabetes in comparison with Sprague Dawley (SD) rats as healthy control. Focusing on early effects of diabetes on bone elasticity, longitudinal wave velocities of animal bones were first determined by a micro-Brillouin scattering technique in a non-destructive way. Wave velocities in the cortical and cancellous bones in the tibias of the SDT and SD rats were compared. In a pre-diabetic stage at approximately 10 weeks of age, there seems no significant difference in wave velocities in bones from age-matched SDT and SD rats. By contrast, after the onset of diabetes at approximately 20 weeks of age, the mean velocities of bones from SDT rats were lower than those of SD rat. In addition, the X-ray CT showed that the bone amounts of SDT rats were smaller than those of SD rats in an early diabetic stage at 20 weeks of age. The current study demonstrated that the wave velocity decreased in bones of SDT rats in the early stages of diabetes. While a decrease of bone strength in an early stage of diabetes can be partially explained from decreases in bone amount as well as bone elasticity, further studies will be needed in understanding a detailed mechanism of bone deterioration due to diabetes.



中文翻译:

长时间的高血糖症会降低II型糖尿病大鼠骨骼的弹性。

据报道,糖尿病患者的骨折风险增加。为了评估葡萄糖耐受不良对骨稳态的早期影响,我们对自发性糖尿病鸟(SDT)大鼠的骨骼进行了特征分析,该大鼠是2型糖尿病动物模型,与Sprague Dawley(SD)大鼠相比,作为健康对照。关注糖尿病对骨骼弹性的早期影响,首先通过微布里渊散射技术以无损方式确定动物骨骼的纵向波速。比较了SDT和SD大鼠胫骨皮质和松质骨中的波速。在大约10周龄的糖尿病前期,年龄相匹配的SDT和SD大鼠的骨骼中的波速似乎没有显着差异。相比之下,大约20周龄的糖尿病发作后,SDT大鼠的骨骼平均速度低于SD大鼠。另外,X射线CT显示在20周龄的糖尿病早期,SDT大鼠的骨量小于SD大鼠的骨量。目前的研究表明,糖尿病早期阶段SDT大鼠骨骼中的波速下降。虽然可以通过减少骨量以及减少骨骼弹性来部分解释糖尿病早期阶段骨强度的下降,但仍需要进一步的研究来了解由糖尿病引起的骨质退化的详细机制。目前的研究表明,糖尿病早期阶段SDT大鼠骨骼中的波速下降。虽然可以通过减少骨量以及减少骨骼弹性来部分解释糖尿病早期阶段骨强度的下降,但仍需要进一步的研究来了解由糖尿病引起的骨质退化的详细机制。目前的研究表明,糖尿病早期阶段SDT大鼠骨骼中的波速下降。虽然可以通过减少骨量以及减少骨骼弹性来部分解释糖尿病早期阶段骨强度的下降,但仍需要进一步的研究来了解由糖尿病引起的骨质退化的详细机制。

更新日期:2020-08-08
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