Quercetin was reported to be crucial for a broad range of activities, including attenuating inflammation, platelet aggregation, capillary permeability, and lipid peroxidation. However, the effect of quercetin in hypertension during pregnancy, was not fully understood. The model of hypertension in pregnancy was established in rats by reduced uterine perfusion pressure (RUPP). Quercetin was administrated by gavage. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured using the CODA 6 BP system. Plasma concentrations of Endothelin-1 (ET-1), soluble fms-like tyrosine kinase-1 (sFlt-1), and vascular endothelial growth factor (VEGF) were detected using enzyme-linked immunosorbent assay kits. The mRNA and protein levels of ET-1 and endothelin-1 type A receptor (ETAR) were determined by RT-PCR and Western blotting. The ETAR antagonist BQ-123 was performed by osmotic minipumps. In RUPP induced rats, quercetin treatment decreased SBP and DBP, fetal resorptions percentage, plasma ET-1 and sFlt-1 concentrations, ET-1 and ETAR levels, but increased fetal body weight and VEGF expression. BQ-123 administration attenuated SBP and DBP, suppressed fatal resorptions percentage, and increased fetal body weight of RUPP rats. Quercetin attenuates RUPP induced hypertension in pregnant rats through the regulation of ET-1 and ETAR.

中文翻译：

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槲皮素通过调节内皮素-1和内皮素-1 A型受体来减轻妊娠大鼠子宫灌注压降低的高血压。

据报道，槲皮素对于广泛的活动至关重要，包括减轻炎症，血小板聚集，毛细血管通透性和脂质过氧化。但是，槲皮素在妊娠期高血压中的作用尚未完全了解。通过降低子宫灌注压（RUPP）在大鼠中建立妊娠高血压模型。槲皮素通过管饲法给药。使用CODA 6 BP系统测量收缩压（SBP）和舒张压（DBP）。使用酶联免疫吸附试剂盒检测血浆内皮素-1（ET-1），可溶性fms样酪氨酸激酶-1（sFlt-1）和血管内皮生长因子（VEGF）的浓度。通过RT-PCR和蛋白质印迹法测定ET-1和内皮素-1型A受体（ETAR）的mRNA和蛋白质水平。通过渗透微型泵进行ETAR拮抗剂BQ-123。在RUPP诱导的大鼠中，槲皮素治疗可降低SBP和DBP，胎儿吸收率，血浆ET-1和sFlt-1浓度，ET-1和ETAR水平，但可增加胎儿体重和VEGF表达。BQ-123给药可减轻RUPP大鼠的SBP和DBP，抑制致命的吸收百分比，并增加胎儿体重。槲皮素通过调节ET-1和ETAR减轻妊娠大鼠RUPP诱发的高血压。并增加RUPP大鼠的胎儿体重。槲皮素通过调节ET-1和ETAR减轻妊娠大鼠RUPP诱发的高血压。并增加RUPP大鼠的胎儿体重。槲皮素通过调节ET-1和ETAR减轻妊娠大鼠RUPP诱发的高血压。