The plant flavonol quercetin causes multiple health-promoting effects in human and animals. In this study, we investigated the possible effects of quercetin on global DNA methylation in growing pigs after 7 weeks of feeding a quercetin-enriched diet. The results indicated that a trend for an improved feed conversion was observed in the quercetin fed group compared to the control group. Furthermore, quercetin influenced global DNA methylation by upregulating DNA methyltransferase 1 (DNMT1) in both mRNA and protein expressions in a tissue specific manner. The observed bioactivity of quercetin against the global methylation marker in pigs indicates that quercetin could be a potential inducer of DNA methylation which might be of economic significance for effective nutritional interventions affecting the health and productivity of animals.

中文翻译：

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槲皮素对猪整体DNA甲基化模式的影响。

植物黄酮醇槲皮素对人类和动物具有多种促进健康的作用。在这项研究中，我们研究了富含槲皮素的饮食7周后槲皮素对生长中的猪整体DNA甲基化的可能影响。结果表明，与对照组相比，槲皮素喂养组观察到了饲料转化率提高的趋势。此外，槲皮素通过以组织特异性方式上调mRNA和蛋白质表达中的DNA甲基转移酶1（DNMT1）来影响整体DNA甲基化。观察到的槲皮素抗猪总体甲基化标记的生物活性表明，槲皮素可能是DNA甲基化的潜在诱导剂，这对于影响动物健康和生产力的有效营养干预措施可能具有经济意义。