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Potential Safety Hazards Associated with Using N,N-Dimethylformamide in Chemical Reactions
Organic Process Research & Development ( IF 3.4 ) Pub Date : 2020-08-06 , DOI: 10.1021/acs.oprd.0c00330
Qiang Yang 1 , Min Sheng 2 , Yongliang Huang 3
Affiliation  

N,N-Dimethylformamide (DMF) is frequently used as a solvent because of its unique physical properties that allow it to solubilize both organic and inorganic substances. It has also found broad applications as a catalyst for a variety of chemical transformations and as a donor for many functional groups in synthetic organic chemistry. However, DMF is incompatible with a wide variety of substances and has resulted in many incidents over the years. Analysis of literature information indicates that those incompatible substances can be categorized as acids, bases, halogenated reagents, oxidants, and reductants. This comprehensive review of the potential hazards of using DMF in chemical reactions will serve as an educational resource to promote awareness of such safety hazards in the broader chemistry community and encourage scientists to develop appropriate control strategies to mitigate the potential safety risks associated with the use of DMF in chemical reactions.

中文翻译:

在化学反应中使用NN-二甲基甲酰胺相关的潜在安全隐患

ññ-二甲基甲酰胺(DMF)由于其独特的物理性质使其可溶解有机和无机物质而经常用作溶剂。还已经发现其广泛地用作各种化学转化的催化剂和合成有机化学中许多官能团的供体。但是,DMF与多种物质不兼容,多年来已导致许多事件。对文献信息的分析表明,那些不相容的物质可分类为酸,碱,卤化试剂,氧化剂和还原剂。
更新日期:2020-09-20
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