Genomic imprinting is a parent-of-origin dependent phenomenon that restricts transcription to predominantly one parental allele. Since the discovery of the first long noncoding RNA (lncRNA), which notably was an imprinted lncRNA, a body of knowledge has demonstrated pivotal roles for imprinted lncRNAs in regulating parental-specific expression of neighboring imprinted genes. In this Review, we will discuss the multiple functionalities attributed to lncRNAs and how they regulate imprinted gene expression. We also raise unresolved questions about imprinted lncRNA function, which may lead to new avenues of investigation. This Review is dedicated to the memory of Denise Barlow, a giant in the field of genomic imprinting and functional lncRNAs. With her passion for understanding the inner workings of science, her indominable spirit and her consummate curiosity, Denise blazed a path of scientific investigation that made many seminal contributions to genomic imprinting and the wider field of epigenetic regulation, in addition to inspiring future generations of scientists.

基因组印记是一种起源于母体的现象，将转录限制为一个亲本等位基因。自发现第一个长非编码RNA（lncRNA）（尤其是印记的lncRNA）以来，一整套知识已证明，印记的lncRNA在调节相邻印记基因的亲本特异性表达中起着关键作用。在这篇综述中，我们将讨论归因于lncRNA的多种功能以及它们如何调节印迹基因的表达。我们还提出了有关印记的lncRNA功能的未解决问题，这可能会导致新的研究途径。这篇评论致力于纪念丹尼斯·巴洛（Denise Barlow），后者是基因组印迹和功能性lncRNA领域的巨头。凭借对理解科学内部原理的热情，