Mitochondria respond to DNA damage and preserve their own genetic material in a manner distinct from that of the nucleus but that requires organized mito–nuclear communication. Failure to resolve mtDNA breaks leads to mitochondrial dysfunction and affects host cells and tissues. Here, we review the pathways that safeguard mitochondrial genomes and examine the insights gained from studies of cellular and tissue-wide responses to mtDNA damage and mito–nuclear genome incompatibility.

中文翻译：

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在高等真核生物中保护线粒体基因组。

线粒体以不同于核的方式响应DNA损伤并保存其自身的遗传物质，但这需要有组织的线粒体-核通讯。无法解析mtDNA断裂会导致线粒体功能障碍，并影响宿主细胞和组织。在这里，我们回顾了保护线粒体基因组的途径，并研究了从细胞和组织范围对mtDNA损伤和线粒体-核基因组不相容性反应的研究中获得的见解。