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Immunometabolism and HIV-1 pathogenesis: food for thought.
Nature Reviews Immunology ( IF 100.3 ) Pub Date : 2020-08-06 , DOI: 10.1038/s41577-020-0381-7
Asier Sáez-Cirión 1 , Irini Sereti 2
Affiliation  

Antiretroviral therapies efficiently block HIV-1 replication but need to be maintained for life. Moreover, chronic inflammation is a hallmark of HIV-1 infection that persists despite treatment. There is, therefore, an urgent need to better understand the mechanisms driving HIV-1 pathogenesis and to identify new targets for therapeutic intervention. In the past few years, the decisive role of cellular metabolism in the fate and activity of immune cells has been uncovered, as well as its impact on the outcome of infectious diseases. Emerging evidence suggests that immunometabolism has a key role in HIV-1 pathogenesis. The metabolic pathways of CD4+ T cells and macrophages determine their susceptibility to infection, the persistence of infected cells and the establishment of latency. Immunometabolism also shapes immune responses against HIV-1, and cell metabolic products are key drivers of inflammation during infection. In this Review, we summarize current knowledge of the links between HIV-1 infection and immunometabolism, and we discuss the potential opportunities and challenges for therapeutic interventions.



中文翻译:

免疫代谢和 HIV-1 发病机制:值得深思。

抗逆转录病毒疗法可有效阻止 HIV-1 复制,但需要终生维持。此外,慢性炎症是 HIV-1 感染的一个标志,尽管进行了治疗,但它仍然存在。因此,迫切需要更好地了解驱动 HIV-1 发病机制的机制并确定治疗干预的新目标。在过去的几年中,人们发现了细胞代谢在免疫细胞的命运和活动中的决定性作用,以及它对传染病结果的影响。新出现的证据表明免疫代谢在 HIV-1 发病机制中起关键作用。CD4 +的代谢途径T 细胞和巨噬细胞决定了它们对感染的易感性、感染细胞的持久性和潜伏期的建立。免疫代谢也塑造了针对 HIV-1 的免疫反应,细胞代谢产物是感染期间炎症的关键驱动因素。在这篇综述中,我们总结了当前关于 HIV-1 感染与免疫代谢之间联系的知识,并讨论了治疗干预的潜在机遇和挑战。

更新日期:2020-08-06
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