Each day, the gastrointestinal tract encounters an influx of microbial and nutrient-derived signals and its physiological activities often adhere to a circadian rhythm. As such, group 3 innate lymphoid cells (ILC3s) that reside in the intestinal mucosa must function within a highly dynamic environment. In this Progress article, we highlight a series of recent reports that have characterized the circadian clock in ILC3s. We discuss how these studies have illustrated the roles of environmental cues and clock genes in regulating ILC3 biology and consider the implications for intestinal immunity.

中文翻译：

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在第3组先天淋巴样细胞中保持时间。

每天，胃肠道都会涌入大量微生物和营养来源的信号，其生理活动通常会遵循昼夜节律。这样，驻留在肠粘膜中的第3组先天淋巴样细胞（ILC3）必须在高度动态的环境中起作用。在这篇“进展”文章中，我们重点介绍了一系列最近的报告，这些报告表征了ILC3中的生物钟。我们讨论这些研究如何说明环境提示和时钟基因在调节ILC3生物学中的作用，并考虑对肠道免疫的影响。