Active metabolites from natural sources are the predominant molecular targets in numerous biological studies owing to their appropriate compatibility with biological systems and desirable selective toxicities. Thus, their potential for therapeutic development could span a broad scope of disease areas, including pathological and neurological dysfunctions. Cardiac glycosides are a unique class of specialized metabolites that have been extensively applied as therapeutic agents for the treatment of numerous heart conditions, and more recently, they have also been explored as probable antitumor agents. They are a class of naturally derived compounds that bind to and inhibit Na⁺/K⁺-ATPase. This study presents cardiac glycosides and their analogues with highlights on their applications, challenges, and prospects as lead compounds for cancer treatment.

中文翻译：

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心脏糖苷在癌症修复中的前景和治疗应用。

由于天然来源的活性代谢物与生物系统的适当相容性和理想的选择性毒性，它们是众多生物学研究中的主要分子靶标。因此，它们的治疗发展潜力可以跨越广泛的疾病领域，包括病理和神经功能障碍。强心苷是一类独特的特殊代谢物，已被广泛用作治疗多种心脏病的治疗剂，最近，它们也被探索为可能的抗肿瘤剂。它们是一类天然衍生的化合物，可结合并抑制 Na ⁺ /K ⁺-ATP酶。本研究介绍了强心苷及其类似物，重点介绍了它们作为癌症治疗先导化合物的应用、挑战和前景。