The authors conducted this meta-analysis to robustly estimate relationships between polymorphisms in VDR gene and the risk of osteoporosis by integrating the results of previous works. Medline, Embase, Wanfang, VIP and CNKI were searched thoroughly for eligible studies, and 73 genetic association studies were finally included in this meta-analysis. We noticed that ApaI rs7975232, BsmI rs1544410 and TaqI rs731236 polymorphisms were significantly associated with the risk of osteoporosis in Caucasians. Moreover, BsmI rs1544410 and FokI rs10735810 polymorphisms were significantly associated with the risk of osteoporosis in Asians. In conclusion, this meta-analysis demonstrates that ApaI rs7975232, BsmI rs1544410 and TaqI rs731236 polymorphisms may influence the risk of osteoporosis in Caucasians, while BsmI rs1544410 and TaqI rs731236 polymorphisms may influence the risk of osteoporosis in Asians.

作者进行了这项荟萃分析，以稳健地估算VDR中多态性之间的关系。综合以前的研究结果，发现该基因与骨质疏松症的风险有关。对Medline，Embase，Wanfang，VIP和CNKI进行了彻底搜索以寻找合格的研究，该荟萃分析最终包括73个遗传关联研究。我们注意到，ApaI rs7975232，BsmI rs1544410和TaqI rs731236多态性与白种人的骨质疏松症风险显着相关。此外，BsmI rs1544410和FokI rs10735810多态性与亚洲人患骨质疏松症的风险显着相关。总之，这项荟萃分析表明，ApaI rs7975232，BsmI rs1544410和TaqI rs731236多态性可能影响白种人的骨质疏松症风险，而BsmI rs1544410和TaqI rs731236多态性可能影响亚洲人骨质疏松症的风险。