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Transcriptional Control of Quality Differences in the Lipid-Based Cuticle Barrier in Drosophila suzukii and Drosophila melanogaster.
Frontiers in Genetics ( IF 3.7 ) Pub Date : 2020-07-20 , DOI: 10.3389/fgene.2020.00887
Yiwen Wang 1, 2 , Jean-Pierre Farine 3 , Yang Yang 1 , Jing Yang 1 , Weina Tang 2 , Nicole Gehring 1 , Jean-François Ferveur 3 , Bernard Moussian 1, 4
Affiliation  

Cuticle barrier efficiency in insects depends largely on cuticular lipids. To learn about the evolution of cuticle barrier function, we compared the basic properties of the cuticle inward and outward barrier function in adults of the fruit flies Drosophila suzukii and Drosophila melanogaster that live on fruits sharing a similar habitat. At low air humidity, D. suzukii flies desiccate faster than D. melanogaster flies. We observed a general trend indicating that in this respect males are less robust than females in both species. Xenobiotics penetration occurs at lower temperatures in D. suzukii than in D. melanogaster. Likewise, D. suzukii flies are more susceptible to contact insecticides than D. melanogaster flies. Thus, both the inward and outward barriers of D. suzukii are less efficient. Consistently, D. suzukii flies have less cuticular hydrocarbons (CHC) that participate as key components of the cuticle barrier. Especially, the relative amounts of branched and desaturated CHCs, known to enhance desiccation resistance, show reduced levels in D. suzukii. Moreover, the expression of snustorr (snu) that encodes an ABC transporter involved in barrier construction and CHC externalization, is strongly suppressed in D. suzukii. Hence, species-specific genetic programs regulate the quality of the lipid-based cuticle barrier in these two Drosophilae. Together, we conclude that the weaker inward and outward barriers of D. suzukii may be partly explained by differences in CHC composition and by a reduced Snu-dependent transport rate of CHCs to the surface. In turn, this suggests that snu is an ecologically adjustable and therefore relevant gene in cuticle barrier efficiency.



中文翻译:

转录控制的质量差异基于脂的角质层屏障在果蝇铃木和果蝇。

昆虫的表皮屏障效率在很大程度上取决于表皮脂质。若要了解角质层屏障功能的演变,我们比较了果蝇成年果皮角质层向内和向外屏障功能的基本特性铃木果蝇果蝇它们生活在有着相似栖息地的水果上。在低空气湿度下铃木D. 蝇干得比 黑腹果蝇苍蝇。我们观察到总体趋势,表明在这方面,两种物种中雄性都没有雌性强壮。异种生物渗透发生在较低的温度下铃木D. 比在 黑腹果蝇。同样铃木D. 苍蝇比接触杀虫剂更易感 黑腹果蝇苍蝇。因此,铃木D.效率较低。一致地,铃木D.果蝇的表皮碳氢化合物(CHC)较少,它们是表皮屏障的关键成分。尤其是,已知可增强耐干燥性的支链和不饱和CHC的相对数量显示出降低的水平。铃木D.。而且,表达监听器nu)编码参与屏障构建和CHC外部化的ABC转运蛋白, 铃木D.。因此,特定于物种的遗传程序调节了这两个果蝇中基于脂质的角质层屏障的质量。综上所述,我们得出的结论是:铃木D.CHC组成的差异和CHC到表面的Snu依赖性转运速率降低可能部分解释了这一点。反过来,这表明nu 是可生态调节的,因此与表皮屏障效率相关的基因。

更新日期:2020-08-06
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