Arylnaphthalene lignan lactones belong to a class of natural lignans, and more than 60 analogs have been isolated. Their pharmacological activities as well as unique structural features have attracted considerable attention from medicinal and synthetic chemists. Since the first synthesis in 1895, many synthetic methodologies with ionic or pericyclic reaction mechanisms have been reported. Transition metal catalysts sometimes provide exceptional synthetic versatility for the syntheses of natural compounds. Recently, transition metal-mediated methodologies were investigated for the construction of basic scaffolds of arylnaphthalene lignan lactones. Five kinds of transition metal catalysts containing gold, manganese, nickel, palladium, and silver have been explored. Most of the metal catalysts successfully created arylnaphthalene lactones by intermolecular or intramolecular annulative cyclization. In this review, all reports of transition metal-mediated annulative construction of arylnaphthalene lignan lactones were compiled, and synthetic approaches, mechanistic aspects, and successful applications were discussed.

芳基萘木脂素内酯属于一类天然木脂素，已分离出60多个类似物。它们的药理活性以及独特的结构特征引起了药物和合成化学家的极大关注。自1895年首次合成以来，已报道了许多具有离子或环周反应机理的合成方法。过渡金属催化剂有时可为天然化合物的合成提供出色的合成多功能性。最近，对过渡金属介导的方法学进行了研究，以建立芳基萘木脂素内酯的基本骨架。已经研究了包含金，锰，镍，钯和银的五种过渡金属催化剂。大多数金属催化剂通过分子间或分子内环化环化成功地生成了芳基萘内酯。在这篇综述中，所有关于过渡金属介导的芳基萘木脂体内酯环化构造的报道都得到了汇编，并讨论了合成方法，机理和成功应用。