Summary Migration of Baylisascaris potosis larvae in different mouse strains were compared, and infectivity of the persisting larvae in mice tissues were investigated. Five strains of mice, BALB/c, C57BL/6, AKR, B10.BR, and ICR were inoculated with 1,000 B. potosis eggs/mouse, and necropsied at week 13 post inoculation (PI). The other uninfected ICR mice (secondary host) were inoculated with 43 larvae/ mouse recovered from mice at week 13 PI with eggs, and necropsied at day 21 PI. Larvae in organs or tissues were counted at necropsy. One AKR mouse showed torticollis and circling at day 56 PI. At necropsy at week 13 PI, larvae were recovered from all mice. A mean total larvae recovered were 124.1 (n=40). Majority of larvae were found in the carcass (mean 113.9) and some in the viscera (mean 9.9). Zero to 1 larva were found in the brain or eyes of some mice. There were no differences among the mouse strains in the number of larvae, except in the viscera; more larvae were seen in BALB/c or ICR than in B10.BR mice. No larvae were found in the secondary host mice. Present study demonstrated that B. potosis larvae migrate well in the carcass of any strains of mice, however, the tissue larvae did not infect the secondary host. Results of our present study suggest that B. potosis larvae is less aggressive for the nervous tissue migration than that of B. procyonis larvae which is commonly known to migrate in central nervous system of mammals and birds.

中文翻译：

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不同品系小鼠贝蛔虫病幼虫及组织幼虫感染性

总结 比较了Baylisascaris potosis 幼虫在不同小鼠品系中的迁移，并研究了持续存在的幼虫在小鼠组织中的传染性。五种品系小鼠，BALB/c、C57BL/6、AKR、B10.BR 和 ICR 用 1,000 个 B.potosis 卵/小鼠接种，并在接种后第 13 周 (PI) 进行尸检。其他未感染的 ICR 小鼠（第二宿主）在接种后第 13 周用从小鼠中回收的 43 只幼虫/小鼠接种，并在接种后第 21 天进行尸体剖检。在尸体剖检时计数器官或组织中的幼虫。一只 AKR 小鼠在接种后第 56 天出现斜颈和盘旋。在第 13 周尸检时，从所有小鼠中回收幼虫。回收的平均总幼虫为 124.1 (n=40)。大多数幼虫在尸体中发现（平均 113.9），一些在内脏中发现（平均 9.9）。在一些老鼠的大脑或眼睛中发现了 0 到 1 个幼虫。除内脏外，小鼠品系之间的幼虫数量没有差异；在 BALB/c 或 ICR 中观察到的幼虫多于 B10.BR 小鼠。在第二宿主小鼠中未发现幼虫。目前的研究表明，B. potosis 幼虫在任何品系小鼠的尸体中都能很好地迁移，然而，组织幼虫不会感染第二宿主。我们目前的研究结果表明，B. potosis 幼虫对神经组织迁移的侵袭性低于众所周知在哺乳动物和鸟类的中枢神经系统中迁移的 B. procyonis 幼虫。在第二宿主小鼠中未发现幼虫。目前的研究表明，B. potosis 幼虫在任何品系小鼠的尸体中都能很好地迁移，然而，组织幼虫不会感染第二宿主。我们目前的研究结果表明，B. potosis 幼虫对神经组织迁移的侵袭性低于众所周知在哺乳动物和鸟类的中枢神经系统中迁移的 B. procyonis 幼虫。在第二宿主小鼠中未发现幼虫。目前的研究表明，B. potosis 幼虫在任何品系小鼠的尸体中都能很好地迁移，然而，组织幼虫不会感染第二宿主。我们目前的研究结果表明，B. potosis 幼虫对神经组织迁移的侵袭性低于众所周知在哺乳动物和鸟类的中枢神经系统中迁移的 B. procyonis 幼虫。