Abstract

This review firstly covers the applications of 2-arylbenzothiazoles as amyloid imaging agents, antitumor agents, and organic luminescent materials. Then we review the recent advances in the synthesis of 2-arylbenzothiazole derivatives. On the one hand, we introduce the approaches for construction of the 2-arylbenzothiazole core, including the following categories: (i) classic condensation of 2-aminothiophenols, (ii) direct arylation of benzothiazoles, (iii) intramolecular cyclization of thiobenzanilides, and (iv) tandem cyclization of anilines/ nitroarenes­ with elemental sulfur or sulfides. On the other hand, the transition-metal-catalyzed direct C–H functionalizations of 2-aryl­benzothiazoles are also involved in this review.

1 Introduction

2 Applications of 2-Arylbenzothiazoles

3 Construction of the 2-Arylbenzothiazole Core

4 Synthesis 2-Arylbenzothiazoles via Direct C–H Functionalization

5 Conclusion

中文翻译：

---

2-芳基苯并噻唑的合成及应用的最新进展

摘要

这篇综述首先涵盖了2-芳基苯并噻唑作为淀粉样蛋白成像剂，抗肿瘤剂和有机发光材料的应用。然后，我们回顾了2-芳基苯并噻唑衍生物合成的最新进展。一方面，我们介绍了构建2-芳基苯并噻唑核心的方法，包括以下类别：（i）2-氨基硫酚的经典缩合；（ii）苯并噻唑的直接芳基化；（iii）硫代苯甲腈的分子内环化；以及（iv）将苯胺/硝基芳烃与元素硫或硫化物串联环化。另一方面，本评论还涉及2-芳基苯并噻唑的过渡金属催化直接CH官能团。

1引言

2 2-芳基苯并噻唑的应用

3 2-芳基苯并噻唑核的构建

4通过直接C–H官能化合成2-芳基苯并噻唑

5结论