Antihypertensive medications are commonly prescribed and well‐studied. Given the widespread use and potential side effects, various theories have been made about the relationship between antihypertensives and malignancy, including melanoma. This review describes the current understanding of the most commonly prescribed antihypertensives and their associations with melanoma. The literature demonstrates that diuretics, specifically hydrochlorothiazide and indapamide, may increase the risk of melanoma. While there is no evidence that antihypertensives have a role in melanoma prevention, non‐selective β‐blocker therapy has been associated with a decreased risk of disease progression and recurrence and may also improve outcomes in patients undergoing immunotherapy. In addition, experimental studies reveal that angiotensin‐converting enzyme inhibitors, angiotensin receptor blockers, and calcium channel blockers have anti‐tumor effects, meriting further study.

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抗高血压药和黑色素瘤：更新评论。

抗高血压药物是常用的处方和充分研究的药物。鉴于其广泛使用和潜在的副作用，关于抗高血压药与恶性肿瘤（包括黑色素瘤）之间的关系已经提出了各种理论。这篇综述描述了目前对最常用的抗高血压药物及其与黑色素瘤关联的理解。文献表明利尿剂，特别是氢氯噻嗪和吲达帕胺，可能会增加黑色素瘤的风险。虽然没有证据表明抗高血压药在黑色素瘤预防中起作用，但非选择性 β 受体阻滞剂治疗与疾病进展和复发风险降低有关，并且还可能改善接受免疫治疗的患者的预后。此外，实验研究表明，血管紧张素转换酶抑制剂，