当前位置: X-MOL 学术Anim. Sci. J. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Distribution of the mutant allele of the DMRT3 gene associated with ambling gaits in Japanese native horse populations.
Animal Science Journal ( IF 2 ) Pub Date : 2020-08-05 , DOI: 10.1111/asj.13431
Ripon Chandra Paul 1, 2 , Trung Ba Nguyen 1, 3, 4 , Yu Okuda 1, 5 , Thu Nu Anh Le 1, 6 , Jovilisi Mosese Dau Tabuyaqona 1 , Yuri Konishi 1 , Yoshi Kawamoto 7, 8 , Ken Nozawa 2 , Tetsuo Kunieda 1, 9
Affiliation  

There are currently eight native horse populations in Japan, namely, Hokkaido, Kiso, Noma, Taishu, Misaki, Tokara, Miyako, and Yonaguni horses. Since locomotion traits, including gaitedness, are important for riding and packing horses, the genetic properties associated with these traits could be informative for understanding the characteristics and history of these horses. In this study, we investigated the distribution of the mutant allele of DMRT3 gene (DMRT3:p.Ser301Ter) associated with ambling gaits in the Japanese native horse. We also examined haplotypes of SNPs in the 83‐kb region including DMRT3 gene by genotyping four SNPs in this region. The results revealed the presence of DMRT3:p.Ser301Ter in the Hokkaido and Yonaguni populations at allele frequencies of 0.18 and 0.02, respectively, and the observed haplotype associated with DMRT3:p.Ser301Ter was estimated as the most common haplotype in the horses in the world. Since DMRT3:p.Ser301Ter has been hypothesized to spread across Eurasian continent from Medieval England after 850 to 900 CE, our findings of the presence of DMRT3:p.Ser301Ter with the common haplotype in the Japanese native horses will provide a new insight into the history of the Japanese native horse, such as considerable level of gene flow from Eurasian continent after 850 to 900 CE.

中文翻译:

日本本土马群中与缓步步态相关的 DMRT3 基因突变等位基因的分布。

日本目前有八种本土马种群,即北海道马、木曾马、野间马、太州马、三崎马、托卡拉马、宫古马和与那国马。由于包括步态在内的运动特征对于骑马和驮马很重要,因此与这些特征相关的遗传特性可以为了解这些马的特征和历史提供信息。在这项研究中,我们调查了与日本本地马的缓步步态相关的DMRT3基因突变等位基因 (DMRT3:p.Ser301Ter) 的分布。我们还检查了 83-kb 区域的 SNP 单倍型,包括DMRT3通过对该区域中的四个 SNP 进行基因分型来确定基因。结果显示 DMRT3:p.Ser301Ter 在北海道和与那国岛种群中的等位基因频率分别为 0.18 和 0.02,观察到的与 DMRT3:p.Ser301Ter 相关的单倍型被估计为马匹中最常见的单倍型世界。由于 DMRT3:p.Ser301Ter 被假设在公元 850 年到 900 年之后从中世纪英格兰传播到欧亚大陆,我们发现 DMRT3:p.Ser301Ter 在日本本土马中存在常见的单倍型,这将为我们提供一个新的见解日本本土马的历史,例如在公元 850 年至 900 年之后从欧亚大陆流出相当水平的基因。
更新日期:2020-08-06
down
wechat
bug