Probiotics are growing alternatives to antibiotics, and can contribute to the prevention and treatment of diseases and enhance livestock production. Lactobacillus (L .) ingluviei is a novel probiotic species with growth‐enhancement effects; however, this species remains poorly understood, and there have been (to our knowledge) no studies focusing on its immunological effects. Here, we isolated L. ingluviei C37 (LIC37) from chicken and evaluated the bacterium's immunomodulatory properties to explore its probiotic potential. Real‐time quantitative PCR and ELISA showed that in vitro exposure of inflammation‐stimulated mouse peritoneal macrophages to heat‐killed LIC37 led to decreases in tumor necrosis factor‐α and interleukin (IL)‐6 levels and an increase in IL‐10. These findings suggested that LIC37 exerts anti‐inflammatory effects by modulating cytokine profiles. This species may be an attractive probiotic bacterial strain for use in animal production.

中文翻译：

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来自鸡的 Lactobacillus ingluviei C37 抑制 LPS 刺激的小鼠巨噬细胞的炎症。

益生菌正在成为抗生素的替代品，有助于预防和治疗疾病并提高牲畜产量。Lactobacillus ( L .) ingluviei是一种新型益生菌，具有促进生长的作用；然而，对该物种的了解仍然很少，而且（据我们所知）还没有针对其免疫学影响的研究。在这里，我们分离出L. ingluviei来自鸡的 C37 (LIC37)，并评估了细菌的免疫调节特性，以探索其益生菌潜力。实时定量 PCR 和 ELISA 表明，炎症刺激的小鼠腹膜巨噬细胞在体外暴露于热灭活的 LIC37，导致肿瘤坏死因子-α 和白细胞介素 (IL)-6 水平降低，IL-10 水平升高。这些发现表明 LIC37 通过调节细胞因子谱发挥抗炎作用。该物种可能是用于动物生产的有吸引力的益生菌菌株。