Psoriasis is an inflammatory disease that arises in genetically predisposed individuals. Chronic skin lesions that contain activated immune cells can persist for years. Systemic inhibition of TNF, IL‐17 and IL‐23 cytokines has revolutionized psoriasis care during the recent decades. Unfortunately, local relapse of disease is common at previously inflamed sites after cessation of treatment. This highlights that fundamental pathologic alterations of the affected tissues are not completely resolved during clinical remission. Here, we present arguments for a local disease memory located in both dermis and epidermis in psoriasis skin. We decipher different cellular components and intercellular crosstalk that sustain local disease memory and amplify disease relapse in human psoriasis. Decrypting the mechanisms underlying the establishment and persistence of pathogenic memory cells in resolved psoriasis may provide new therapeutic perspectives aimed at long‐term remission of psoriasis.

中文翻译：

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复发性牛皮癣中的细胞疤痕和局部串扰：皮肤粘着病的一个例子。

牛皮癣是一种遗传性易感个体中发生的炎症性疾病。含有活化免疫细胞的慢性皮肤病变可以持续数年。在近几十年来，对TNF，IL-17和IL-23细胞因子的全身性抑制已经彻底改变了牛皮癣的治疗方法。不幸的是，停止治疗后，在先前发炎的部位，疾病局部复发是常见的。这突显出在临床缓解期间，受影响组织的基本病理改变并未完全解决。在这里，我们提出了牛皮癣皮肤中真皮和表皮都存在局部疾病记忆的观点。我们破译了维持局部疾病记忆并扩大人类牛皮癣疾病复发的不同细胞成分和细胞间串扰。