Nonthermal atmospheric pressure plasma processes, including an interaction between plasma and liquid phases, are employed to induce crosslinked gelatin–graphene oxide composite hydrogels. The properties of thin‐film hydrogel‐forming postplasma treatment are analyzed by infrared spectroscopy, rheology, scanning electron microscope, and in vitro studies. The plasma‐treated hydrogel (PT) exhibits an excellent gel strength with storage modulus up to 341 kPa and thermal stability of gel–sol transition at 65°C, elongated degradation time, and favorable cell viability. The practical application of PT demonstrates an efficient encapsulation and sustainable release of alendronate for at least 21 days. The results show that using nonthermal plasmas can be regarded as an alternative physical method to fabricate composite hydrogels for promising applications in drug carriers and biomedicine.

中文翻译：

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非热常压等离子体诱导的明胶-氧化石墨烯交联用于阿仑膦酸盐的递送系统

非热大气压等离子体过程，包括等离子体和液相之间的相互作用，被用来诱导交联的明胶-氧化石墨烯复合水凝胶。通过红外光谱，流变学，扫描电子显微镜和体外研究分析了形成薄膜水凝胶的等离子体处理的特性。经等离子体处理的水凝胶（PT）具有出色的凝胶强度，储能模量高达341 kPa，在65°C时凝胶-溶胶转变具有热稳定性，延长了降解时间，并具有良好的细胞活力。PT的实际应用证明了阿仑膦酸盐的有效包封和可持续释放至少21天。