A highly stable, versatile, and stimuli‐responsive layer‐by‐layer coating is constructed for mesoporous silica nanoparticles (MSNs) using kinetically trapped host–guest complexation. The ultraslow dissociation kinetics of host–guest complexation ascertains the stability of supramolecular polymeric coating under the complex physiological condition of blood serum. The coating serves as the gatekeeper for nanovalve with zero premature release and the substrate for surface modification with polyethylene glycol or fluorescent dye via host–guest interaction. Under redox stimuli (glutathione), the nanovalve is opened to release the cargo (doxorubicin). The release rate is tunable depending on coating thickness. Polymer coated MSNs are used for the encapsulation and controlled release of doxorubicin in vitro.

中文翻译：

---

基于动力学捕获的宿主-客体络合的介孔二氧化硅纳米粒子的超稳定和通用的多层涂层

使用动力学捕获的主客体络合物，为介孔二氧化硅纳米粒子（MSN）构建了高度稳定，通用且具有刺激响应的逐层涂层。主客体络合的超慢解离动力学确定了在复杂的血清生理条件下超分子聚合物涂层的稳定性。该涂层是零释放的纳米阀的守门员，是通过主客体相互作用用聚乙二醇或荧光染料进行表面改性的基质。在氧化还原刺激（谷胱甘肽）下，打开纳米阀释放货物（阿霉素）。释放速率可根据涂层厚度调节。聚合物包被的MSN用于体外阿霉素的包封和控释。