Sanghuangporus vaninii, called “Sanghuang,” is orally used for health care, tumor, and inflammation treatment in Asia. However, the safety of S. vaninii has not been evaluated. The major compounds analysis showed that aqueous extracts of S. vaninii fruiting body were rich in polysaccharides, nucleotides, and polyphenols. Then, the aqueous was given orally to Sprague–Dawley rats for toxical test. In acute toxicity study, the maximum tolerated dose was 21 g/kg. In 17‐week repeated dose toxicity experiment, all rats had no abnormal reaction among control group, low dose group (0.15 g/kg) and middle dose group (1.00 g/kg). At high dose group (6.00 g/kg), the feces began to darken on 16th day (D16), and turned to drug stained stool on D21, all rats recovered on the 3rd day (D92) of recovery period. During the whole experiment, there were no animal death and no treatment‐related changes in any of the parameters under the all doses. These results indicated the No‐Observed Adverse Effect Level of aqueous extract of S. vaninii fruiting body was 1.0 g/kg.

中文翻译：

---

Sangagueporus vaninii子实体水提物对Sprague-Dawley大鼠的安全性评价

桑桑黄孢子虫（Sanghuangporus vaninii）在亚洲被口服用于医疗保健，肿瘤和炎症治疗。但是，尚未评估香草葡萄球菌的安全性。主要化合物分析表明，瓦氏链球菌的水提物子实体富含多糖，核苷酸和多酚。然后，将水剂口服给予Sprague-Dawley大鼠以进行毒性测试。在急性毒性研究中，最大耐受剂量为21 g / kg。在17周的重复剂量毒性实验中，对照组，低剂量组（0.15 g / kg）和中剂量组（1.00 g / kg）之间的所有大鼠均无异常反应。在高剂量组（6.00 g / kg），粪便在第16天（D16）开始变黑，并在D21变成粪便染色，所有大鼠在恢复期的第3天（D92）恢复。在整个实验过程中，所有剂量下所有参数均无动物死亡和治疗相关变化。这些结果表明，瓦氏链球菌子实体水提物的未观察到不良反应水平为1.0 g / kg。