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Antiepileptic combination therapy with Stevens‐Johnson syndrome and toxic epidermal necrolysis: Analysis of a Japanese pharmacovigilance database
Epilepsia ( IF 5.6 ) Pub Date : 2020-08-06 , DOI: 10.1111/epi.16626
Yoshihiro Noguchi 1 , Mirai Takaoka 1 , Tsuyoshi Hayashi 1 , Tomoya Tachi 1 , Hitomi Teramachi 1, 2
Affiliation  

Stevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are immune‐mediated diseases characterized by an extensive loss of the epidermal skin layer, often resulting in death. SJS and TEN are often triggered by certain drugs, including antiepileptic drugs (AEDs). Epilepsy is very difficult to treat and often involves the combination of two or more AEDs. In this study, we quantified not only the risk of SJS or TEN associated with single‐AED therapy but also the risk related to concomitant AED treatment using reporting‐derived signals.

中文翻译:

Stevens-Johnson 综合征和中毒性表皮坏死松解症的抗癫痫联合治疗:日本药物警戒数据库分析

史蒂文斯-约翰逊综合征 (SJS) 和中毒性表皮坏死松解症 (TEN) 是免疫介导的疾病,其特征是表皮皮肤层大量丧失,通常会导致死亡。SJS 和 TEN 通常由某些药物引发,包括抗癫痫药 (AED)。癫痫非常难以治疗,通常涉及两种或多种 AED 的组合。在这项研究中,我们不仅量化了与单一 AED 治疗相关的 SJS 或 TEN 的风险,而且还使用报告衍生信号量化了与伴随 AED 治疗相关的风险。
更新日期:2020-08-06
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