In the yeast Saccharomyces cerevisiae, acute glucose starvation induces rapid endocytosis followed by vacuolar degradation of many plasma membrane proteins. This process is essential for cell viability, but the regulatory mechanisms that control it remain poorly understood. Under normal growth conditions, a major regulatory decision for endocytic cargo occurs at the trans‐Golgi network (TGN) where proteins can recycle back to the plasma membrane or can be recognized by TGN‐localised clathrin adaptors that direct them towards the vacuole. However, glucose starvation reduces recycling and alters the localization and post‐translational modification of TGN‐localised clathrin adaptors. This raises the possibility that during glucose starvation endocytosed proteins are routed to the vacuole by a novel mechanism that bypasses the TGN or does not require TGN‐localised clathrin adaptors.

中文翻译：

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由葡萄糖饥饿诱导的质膜到液泡的运输需要在跨高尔基网络中依赖 Gga2 进行分选

在酵母 Saccharomyces cerevisiae 中，急性葡萄糖饥饿会诱导快速内吞作用，随后许多质膜蛋白发生液泡降解。这个过程对于细胞活力至关重要，但控制它的调节机制仍然知之甚少。在正常生长条件下，内吞货物的主要监管决定发生在反式高尔基网络 (TGN)，在那里蛋白质可以循环回到质膜，或者可以被 TGN 定位的网格蛋白接头识别，将它们引导至液泡。然而，葡萄糖饥饿会减少回收并改变 TGN 定位的网格蛋白接头的定位和翻译后修饰。