Analytical methods that allow simultaneous determination of the concentration and enantiomeric composition of small sample amounts and are also compatible with high‐throughput multi‐well plate technology have received increasing attention in recent years. We now introduce a new class of broadly useful small‐molecule probes and a relay sensing strategy that together accomplish these tasks with five classes of compounds including the challenging group of mono‐alcohols—a scope that stands out among previously reported UV, fluorescence, and CD assays. Several chlorophosphite probes and aniline indicators have been evaluated and used for on‐the‐fly CD/UV sensing following a continuous workflow. The wide application range of the readily available sensors is highlighted with almost 30 alcohols, diols, hydroxy acids, amines and amino alcohols, and the accuracy of the stereochemical analysis is showcased with samples covering a wide range of concentrations and enantiomeric ratios.

中文翻译：

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在中继分析中使用亚氯酸盐传感器对醇，二醇，羟基酸，胺和氨基醇进行定量手性和浓度检测。

允许同时测定少量样品的浓度和对映体组成的分析方法，并且还与高通量多孔板技术兼容，近年来受到越来越多的关注。现在，我们介​​绍一类新的广泛使用的小分子探针和一种中继传感策略，它们可以与五类化合物一起完成这些任务，其中包括具有挑战性的一元醇类（该类化合物在以前报道的UV，荧光和CD分析。经过连续的工作流程，已评估了几种亚氯酸盐探针和苯胺指示剂，并将其用于动态CD / UV感测。现成的传感器广泛的应用范围突出了近30种醇，二醇，羟基酸，胺和氨基醇，