Human rhinovirus (HRV) affects the lower and upper respiratory tract, however, some studies suggest that HRV infection can lead to extrapulmonary complications in critical illness. Moreover, some reports have shown the presence of HRV in patients with Central Nervous System (CNS) disease. During a CNS infection, the microglia cells are the first line of defense against pathogens. In this study, the susceptibility of the human microglial clone 3 cell line (HMC3) to HRV infection was analyzed. Our findings demonstrate for the first time that HRV is capable of completing the entire viral cycle in microglial cells.

中文翻译：

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小胶质细胞 HMC3 细胞对鼻病毒感染高度敏感。

人类鼻病毒 (HRV) 影响下呼吸道和上呼吸道，然而，一些研究表明 HRV 感染可导致危重疾病的肺外并发症。此外，一些报告显示中枢神经系统 (CNS) 疾病患者存在 HRV。在中枢神经系统感染期间，小胶质细胞是抵御病原体的第一道防线。在这项研究中，分析了人小胶质细胞克隆 3 细胞系 (HMC3) 对 HRV 感染的易感性。我们的研究结果首次证明 HRV 能够在小胶质细胞中完成整个病毒周期。