Biocompatible BPA-PPD polyimide is widely used in the packaging of implantable devices. Plasma activation can improve its interaction with the surrounding tissue upon implantation. The influence of He, air, N₂ and Ar plasma activation on polyimide's surface hydrophilicity, roughness, topography, composition and cell-surface interaction was evaluated, along with the influence of hydrophobic recovery on such properties. All plasma activations increased the surface hydrophilicity but neither the roughness nor topography changed. The increase was attributed to the incorporated O- and N-functionalities. 24 h after the activations the surface hydrophilicity decreased while maintaining the functionalities, due to the functionalities’ reorientation/migration towards the bulk of polyimide. Air and N₂ activations improved the cell-surface interactions with fibroblasts. These were equally influenced by the surface hydrophilicity and the surface functionalities availability. The hydrophobic recovery lowered the initial cell adhesion but not the cell proliferation, as the hydrophobic recovery was progressively reversed in the culture media.

生物相容性BPA-PPD聚酰亚胺广泛用于可植入设备的包装中。植入后，血浆激活可以改善其与周围组织的相互作用。评估了He，空气，N ₂和Ar等离子体活化对聚酰亚胺表面亲水性，粗糙度，形貌，组成和细胞表面相互作用的影响，以及疏水回收对此类性能的影响。所有等离子体活化均增加了表面亲水性，但粗糙度和形貌均未改变。增加归因于合并的O和N功能。活化后24小时，由于官能团向聚酰亚胺主体的重新取向/迁移，表面亲水性在保持官能团的同时下降。空气和N ₂活化改善了细胞与成纤维细胞的相互作用。这些同样受到表面亲水性和表面功能可用性的影响。疏水性恢复降低了初始细胞粘附，但没有降低细胞增殖，因为疏水性恢复在培养基中逐渐逆转。