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Mechanical regulation of cell size, fate, and behavior during asymmetric cell division.
Current Opinion in Cell Biology ( IF 7.5 ) Pub Date : 2020-08-05 , DOI: 10.1016/j.ceb.2020.07.002
Melissa K Delgado 1 , Clemens Cabernard 1
Affiliation  

Asymmetric cell division (ACD) is an evolutionary conserved mechanism used by prokaryotes and eukaryotes alike to generate cell diversity. ACD can be manifested in biased segregation of macromolecules or differential partitioning of cell organelles. Cells are also constantly subject to extrinsic or intrinsic mechanical forces, influencing cell behavior and fate. During ACD, cell intrinsic forces generated through the spatiotemporal regulation of the actomyosin cytoskeleton can influence sibling cell size. External mechanical stresses are further translated by transcriptional coactivators or mechanically gated ion channels. Here, we will discuss recent literature, exploring how mechanical cues influence various aspects of ACD and stem cell behavior, and how these mechanical cues contribute to cell fate decisions.



中文翻译:

在不对称细胞分裂过程中对细胞大小、命运和行为的机械调节。

不对称细胞分裂 (ACD) 是一种进化保守机制,原核生物和真核生物都使用它来产生细胞多样性。ACD 可以表现为大分子的偏分离或细胞器的差异分配。细胞也不断受到外在或内在机械力的影响,影响细胞的行为和命运。在 ACD 期间,通过肌动球蛋白细胞骨架的时空调节产生的细胞内在力可以影响同胞细胞的大小。外部机械应力由转录共激活因子或机械门控离子通道进一步翻译。在这里,我们将讨论最近的文献,探索机械线索如何影响 ACD 和干细胞行为的各个方面,以及这些机械线索如何影响细胞命运决定。

更新日期:2020-08-06
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