Achieving high selectivity through multiple C–H functionalization is a challenging task. In this issue of Chem, Lumb, Luan, and co-workers disclose a clever strategy taking advantage of steric remote effects for the synthesis of poly-substituted arenes through a 4-component Catellani reaction with remarkable regio- and chemoselectivity by using readily available reagents.

中文翻译：

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选择性双重C–H功能化：4组分卡塔尼反应

通过多个C–H功能化实现高选择性是一项艰巨的任务。在本期《化学》杂志上，伦布，卢安和他的同事们揭示了一种巧妙的策略，即利用空间遥远的效应，通过使用易于获得的试剂通过4组分卡塞拉尼反应合成具有多价区域和化学选择性的多取代芳烃。 。