Brain Imaging and Behavior ( IF 3.2 ) Pub Date : 2020-08-06 , DOI: 10.1007/s11682-019-00203-7 Bin Wang 1, 2 , Yaqing Hao 1 , Qionghui Zhan 1 , Shuo Zhao 3 , Dandan Li 1 , Sumaira Imtiaz 1 , Jie Xiang 1 , Jinglong Wu 4, 5 , Hidenao Fukuyama 2, 5 , Ting Yan 1
Response inhibition is the ability to suppress automatic actions or behaviors that are not appropriate or are no longer adaptive to the situation. Although many studies have suggested regional brain activation, the nature of the reconfiguration of functional brain networks involved in response inhibition remains unknown. Here, we assessed brain changes associated with response inhibition using graph theoretical analysis applied to functional connectivity data acquired while subjects performed a simple stop-signal task. We identified several ways in which global network organization shifted to meet the demand for response inhibition. Increased demand for response inhibition was associated with a global network configuration with more efficient communication across the network (functional integration) and more specialized processing (functional segregation). Regions distributed in the frontoparietal network and attention networks were found to be highly efficient in the stop condition. Nodal efficiency was significantly associated with reaction time and showed a different pattern between the go and stop conditions. In addition, the conditional differences (stop vs. go) in nodal efficiency and regional task activation were common in the postcentral gyrus (PoCG) and superior temporal lobe gyrus (STG), and a negative correlation between these differences was found in the frontal and parietal lobes. These results provide compelling evidence that response inhibition is associated with truly global changes in brain functional connectivity and additional insights into how defects in response inhibition are associated with neurological or psychiatric difficulties.
中文翻译:
支持停止信号任务中响应抑制的功能性大脑网络的动态重构。
反应抑制是抑制不适当或不再适应情况的自动动作或行为的能力。尽管许多研究表明区域性大脑激活,但参与反应抑制的功能性大脑网络重构的性质仍然未知。在这里,我们使用图论分析评估了与反应抑制相关的大脑变化,该分析应用于在受试者执行简单的停止信号任务时获取的功能连接数据。我们确定了全球网络组织转变以满足响应抑制需求的几种方式。对响应抑制的需求增加与全球网络配置相关,具有更有效的跨网络通信(功能集成)和更专业的处理(功能隔离)。发现分布在额顶叶网络和注意力网络中的区域在停止条件下非常有效。节点效率与反应时间显着相关,并且在开始和停止条件之间显示出不同的模式。此外,在中央后回 (PoCG) 和颞叶上回 (STG) 中节点效率和区域任务激活的条件差异(停止与执行)很常见,并且在额叶和额叶中发现这些差异之间存在负相关顶叶。