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Left amygdala volume and brain tissue pulsatility are associated with neuroticism: an MRI and ultrasound study.
Brain Imaging and Behavior ( IF 3.2 ) Pub Date : 2020-08-06 , DOI: 10.1007/s11682-020-00348-w
Marta Andrea Siragusa 1 , Thomas Rufin 2 , Robert Courtois 3, 4 , Catherine Belzung 1 , Frédéric Andersson 1 , Bruno Brizard 1 , Paul-Armand Dujardin 5 , Jean-Philippe Cottier 1, 2 , Frédéric Patat 1, 2, 5 , Jean-Pierre Réméniéras 1 , Valérie Gissot 5 , Wissam El-Hage 1, 2, 5 , Vincent Camus 1, 2 , Thomas Desmidt 1, 2
Affiliation  

Brain changes associated with the personality trait of neuroticism have been partly elucidated. While subcortical brain volume changes, especially a larger amygdala, appear consistent in high neuroticism, functional changes, such as cerebral blood flow (CBF) differences, have shown conflicting results, possibly because of the limitations in methods of CBF measurement. In our study, we investigated changes in amygdala volume and CBF-related function associated with neuroticism in healthy and depressed subjects using both conventional magnetic resonance imaging (MRI) measures of brain volume and the innovative technique of ultrasound Tissue Pulsatility Imaging (TPI), which has a high level of detection in measuring brain tissue pulsatility (BTP). Middle-aged females with depression (n = 25) and without depression (n = 25) underwent clinical examination, magnetic resonance imaging (MRI) and ultrasound assessment (TPI). Neuroticism was positively associated with left amygdala volume and mean BTP in individuals without depression, in both simple and multiple regressions that included potential confounding factors such as age and body mass index. No association was found in the depressed group. We confirmed the role of the left amygdala in the brain physiology of neuroticism in nondepressed individuals. Moreover, we identified a novel mechanism associated with high neuroticism, namely BTP, that may reflect greater CBF and account for the increased risk of cerebrovascular disease in individuals with high neuroticism. Because neuroticism is considered a risk factor for depression, our paper provides potential objective biomarkers for the identification of subjects at risk for depression.



中文翻译:

左杏仁核体积和脑组织搏动性与神经质相关:MRI和超声研究。

与神经质人格特征相关的大脑变化已得到部分阐明。在高度神经质的情况下,尽管皮层下的大脑体积变化(尤其是较大的杏仁核)表现出一致,但功能变化(例如脑血流量(CBF)差异)却显示出矛盾的结果,可能是由于CBF测量方法的局限性所致。在我们的研究中,我们使用常规的脑部磁共振成像(MRI)量度和超声组织搏动性成像(TPI)的创新技术,研究了健康人和抑郁症患者的杏仁核体积和与神经质相关的CBF相关功能的变化。在测量脑组织搏动性(BTP)方面具有很高的检测水平。中年女性抑郁症(n = 25)且无抑郁(n = 25)接受了临床检查,磁共振成像(MRI)和超声评估(TPI)。神经质与无抑郁个体的左杏仁核体积和平均BTP呈正相关,包括简单的回归和多重回归,包括年龄和体重指数等潜在的混淆因素。在抑郁组中未发现关联。我们证实了左杏仁核在非抑郁个体神经质的大脑生理中的作用。此外,我们发现了一种与高度神经质相关的新机制,即BTP,该机制可能反映出较高的CBF并解释了高度神经质患者脑血管疾病的风险增加。由于神经质被认为是抑郁的危险因素,

更新日期:2020-08-06
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