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Magnetosome mediated oral Insulin delivery and its possible use in diabetes management.
Journal of Materials Science: Materials in Medicine ( IF 3.7 ) Pub Date : 2020-08-05 , DOI: 10.1007/s10856-020-06417-2
Varalakshmi Raguraman 1 , M A Jayasri 1 , K Suthindhiran 1
Affiliation  

Our study investigates the effect of magnetosome mediated oral Insulin delivery on diabetic induced rat models. The study involves the development of Magnetosome-Insulin (MI) conjugates by direct and indirect (by means of PEG) coupling method and further characterized by microscopic and spectroscopic analysis. The in vivo oral delivery of magnetosome-Insulin conjugate against streptozotocin-induced rat models and its efficiency was investigated. The impact of MI showed a remarkable change in the reduction of FBG levels up to 65% than the standard (Insulin). Similarly, the serum parameters: triglycerides (43.81%), AST&ALT (39.4 and 57.2%), total cholesterol (43.8%) showed significant changes compared to the diabetic control. The histological results of MI treated rats were found similar to control rats. Thus, these significantly notable results on diabetic rats depicts that magnetosomes can be employed as a potential approach and a very promising alternative for the parenteral route of Insulin delivery.



中文翻译:

磁小体介导的口服胰岛素递送及其在糖尿病治疗中的可能用途。

我们的研究调查了磁小体介导的口服胰岛素递送对糖尿病诱导的大鼠模型的影响。该研究涉及通过直接和间接(借助PEG)偶联方法开发磁小体-胰岛素(MI)共轭物,并通过显微镜和光谱分析进一步表征。研究了磁链体-胰岛素偶联物对链脲佐菌素诱导的大鼠模型的体内口服给药及其效率。心肌梗死的影响表明,FBG水平的降低比标准品(胰岛素)降低了65%。同样,与糖尿病对照组相比,血清参数:甘油三酸酯(43.81%),AST&ALT(39.4和57.2%),总胆固醇(43.8%)表现出显着变化。发现MI治疗的大鼠的组织学结果与对照大鼠相似。从而,

更新日期:2020-08-06
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