Abstract

Synthetic efforts toward the synthesis of (+)-lyconadin A are described. B-Alkyl Suzuki coupling is utilized for combining 2-iodo cyclohexenone with the piperidine subunit. The piperidine subunit is derived from 5-bromo-3-nicotinic acid, and iodo cyclohexenone from commercially available (R)-pulegone. An intramolecular Michael reaction is employed for the creation of the C6-C7 bond.

Graphic Abstract

Synthetic efforts toward the synthesis of (+)-lyconadin A are described. B-Alkyl Suzuki coupling is utilized to combine 2-iodo cyclohexenone with the piperidine subunit. The piperidine subunit is derived from 5-bromo-3-nicotinic acid, and iodo cyclohexenone from commercially available (R)-pulegone. An intramolecular Michael reaction is employed for creation of the C6-C7 bond.

中文翻译：

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合成（+）-Lyconadin A的努力

摘要

描述了合成（+）-lyconadin A的合成方法。B-烷基Suzuki偶联用于将2-碘代环己烯酮与哌啶亚基结合。哌啶亚基衍生自5-溴-3-烟酸，碘代环己烯酮衍生自可商购的（R）-普勒高酮。分子内迈克尔反应用于产生C6-C7键。

图形摘要

描述了合成（+）-lyconadin A的合成方法。B-烷基Suzuki偶联用于将2-碘代环己烯酮与哌啶亚基结合。哌啶亚基衍生自5-溴-3-烟酸，碘代环己烯酮衍生自可商购的（R）-普勒高酮。分子内迈克尔反应用于产生C6-C7键。