Abstract

The aims of this study were to determine the expression of Bcl-2 in endometrial adenocarcinomas in imprint smears as an alternative technique rather than the frozen section and to correlate the results with clinicopathologic parameters of primary untreated endometrial cancer patients. One hundred twenty-six patients with endometrial carcinoma were evaluated with samples freshly resected after a total abdominal hysterectomy during a 29-month period. One hundred two cases were type I and 24 type II endometrial adenocarcinomas. Positive expression of Bcl-2 was observed only in type I and in low grade carcinomas. Immunocytochemical findings from Bcl-2 stain, appeared to be a valuable predictor of endometrial cancer diagnosis and postoperative prognosis in most cases in endometrial cytology with imprint smears. Furthermore, positive expression of Bcl-2 was related to morphologic features of less aggressiveness (pathogenetic type I, low-grade, early advanced stage, deep myometrial involvement <1/2 or not) tumors.

中文翻译：

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Bcl-2在子宫内膜癌印记涂片中的表达

摘要

这项研究的目的是确定烙印涂片中子宫内膜腺癌中Bcl-2的表达，作为替代技术而不是冷冻切片，并将结果与​​未经治疗的原发性子宫内膜癌患者的临床病理参数相关联。对29例子宫内膜癌患者进行了29个月的全腹子宫切除后新鲜切除的标本进行了评估。I型和24型子宫内膜腺癌102例。Bcl-2阳性表达仅在I型和低度癌中观察到。Bcl-2染色的免疫细胞化学结果似乎是子宫内膜癌诊断和术后预后的重要预测指标，在大多数情况下，子宫内膜细胞学上有印记涂片。此外，