Nanotechnology has a remarkable impact on the preclinical development of future medicines. However, the complicated preparation and systemic toxicity to living systems prevent them from translation to clinical applications. In the present report, we developed a polyepicatechin-based on/off switchable ultra-sensitive magnetic resonance imaging (MRI) visible theranostic nanoparticle (PEMN) for image-guided photothermal therapy (PTT) using our strategy of integrating polymerization and biomineralization into the protein template. We have exploited natural polyphenols as the near infra-red (NIR) switchable photothermal source and MnO₂ for the MRI-guided theranostics. PEMN demonstrates excellent MRI contrast ability with a longitudinal relaxivity value up to 30.01 mM⁻¹ s⁻¹. PEMN has shown great tumor inhibition on orthotopic breast tumors and the treatment could be made switchable with an on/off interchangeable mode as needed. PEMN was found to be excretable mainly through the kidneys, avoiding potential systemic toxicity. Thus, PEMN could be extremely useful for developing on-demand therapeutics via ‘see it and treat it’ means with distinguished MRI capability and on/off switchable photothermal properties.

中文翻译：

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开启/关闭基于表儿茶素的超灵敏MRI可见纳米治疗-对其进行治疗。

纳米技术对未来药物的临床前开发具有显着影响。然而，复杂的制备和对生命系统的系统毒性使其无法转化为临床应用。在本报告中，我们使用将聚合和生物矿化整合到蛋白质中的策略，开发了一种基于聚表儿茶素的开/关可切换超灵敏磁共振成像（MRI）可见治疗性纳米粒子（PEMN），用于图像引导光热疗法（PTT）。模板。我们已经利用天然多酚作为近红外（NIR）可切换光热源和MnO ₂用于MRI引导的治疗学。PEMN表现出出色的MRI对比能力，纵向弛豫值高达30.01 mM ^-1s ^-1。PEMN已显示出对原位乳腺肿瘤的强大肿瘤抑制作用，可以根据需要使用开/关互换模式来切换治疗。发现PEMN主要通过肾脏排泄，避免了潜在的全身毒性。因此，PEMN对于通过“查看并治疗”手段开发按需治疗方法极其有用，它具有出色的MRI能力和开/关可切换的光热特性。