The enzyme-regulated healable polymeric hydrogels are a kind of emerging soft material capable of repairing the structural defects and recovering the hydrogel properties, wherein their fabrication, self-healing, or degradation is mediated by enzymatic reactions. Despite achievements that have been made in controllable cross-linking and de-cross-linking of hydrogels by utilizing enzyme-catalyzed reactions in the past few years, this substrate-specific strategy for regulating healable polymeric hydrogels remains in its infancy, because both the intelligence and practicality of current man-made enzyme-regulated healable materials are far below the levels of living organisms. A systematic summary of current achievements and a reasonable prospect at this point can play positive roles for the future development in this field. This Outlook focuses on the emerging and rapidly developing research area of bioinspired enzyme-regulated self-healing polymeric hydrogel systems. The enzymatic fabrication and degradation of healable polymeric hydrogels, as well as the enzymatically regulated self-healing of polymeric hydrogels, are reviewed. The functions and applications of the enzyme-regulated healable polymeric hydrogels are discussed.

中文翻译：

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酶调节的可修复聚合物水凝胶

酶调节的可修复聚合物水凝胶是一种新兴的柔软材料，能够修复结构缺陷并恢复水凝胶特性，其中其制备，自我修复或降解是通过酶促反应来介导的。尽管在过去几年中通过利用酶催化反应在水凝胶的可控交联和去交联方面取得了一些成就，但这种调节可修复聚合物水凝胶的特定于底物的策略仍处于起步阶段，因为这两种智能目前人造酶调节的可治愈材料的实用性和实用性远远低于活生物体的水平。目前取得的成就的系统总结和目前的合理前景可以为该领域的未来发展发挥积极作用。本《展望》重点关注生物启发的酶调节的自修复聚合物水凝胶系统的新兴和快速发展的研究领域。审查了可修复的聚合物水凝胶的酶促制备和降解以及聚合物水凝胶的酶促调控的自修复。讨论了酶调节的可修复聚合物水凝胶的功能和应用。