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Serum bicarbonate level improves specificity of Berlin Sleep Questionnaire for obstructive sleep apnea.
The Aging Male ( IF 2.6 ) Pub Date : 2020-08-05 , DOI: 10.1080/13685538.2020.1801623
Mazlum Dursun 1 , Hadice Selimoğlu Şen 1 , Süreyya Yılmaz 1 , Melike Demir 1 , Gökhan Kırbaş 1 , Mahşuk Taylan 2
Affiliation  

Several questionnaires have been developed to assist the diagnostic process in obstructive sleep apnea syndrome (OSAS). Berlin Sleep Questionnaire (BSQ) represents a validated screening tool for OSAS. Totally 450 patients admitted to the Sleep Center at Dicle University Medical Faculty were included prospectively. A risk analysis was performed for presence of OSAS using the BSQ. Arterial blood gas measurements were performed including bicarbonate (HCO3) level. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of BSQ for presence of OSAS and severe OSAS were determined. In patients with arterial HCO3 >24.94 mEq/L; sensitivity, specificity, PPV and NPV, of the BSQ were 93.04, 57.1, 98.3, and 23.5%, respectively. The addition of arterial HCO3 value increased the sensitivity of the BSQ in detecting OSAS patients. Although the cost of sleep studies is high for false positives from the BSQ plus arterial HCO3 level, this cost should be compared with the loss of work efficiency and severe healthcare costs of undiagnosed cases in the future. Therefore, finding possible OSAS cases in primary care health centers is important and adding serum HCO3 value to BSQ questionnaire may contribute to this topic.



中文翻译:

血清碳酸氢盐水平提高了柏林睡眠问卷对阻塞性睡眠呼吸暂停的特异性。

已经开发了几份问卷来协助阻塞性睡眠呼吸暂停综合征 (OSAS) 的诊断过程。柏林睡眠问卷 (BSQ) 是一种经过验证的 OSAS 筛查工具。共有 450 名进入 Dicle 大学医学院睡眠中心的患者被前瞻性纳入。使用 BSQ 对 OSAS 的存在进行了风险分析。进行动脉血气测量,包括碳酸氢盐 (HCO3) 水平。测定了 BSQ 对 OSAS 和严重 OSAS 存在的敏感性、特异性、阳性预测值 (PPV) 和阴性预测值 (NPV)。动脉 HCO 3 >24.94 mEq/L的患者;BSQ 的敏感性、特异性、PPV 和 NPV 分别为 93.04、57.1、98.3 和 23.5%。添加动脉 HCO 3值增加了 BSQ 在检测 OSAS 患者中的敏感性。尽管 BSQ 加动脉 HCO3 水平的假阳性导致睡眠研究的成本很高,但应将此成本与未来未确诊病例的工作效率损失和严重的医疗保健成本进行比较。因此,在初级保健卫生中心发现可能的 OSAS 病例很重要,将血清 HCO3 值添加到 BSQ 问卷可能有助于该主题。

更新日期:2020-08-05
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