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Experience and activity-dependent control of glucocorticoid receptors during the stress response in large-scale brain networks
Stress ( IF 2.3 ) Pub Date : 2020-08-26 , DOI: 10.1080/10253890.2020.1806226
Damien Huzard 1 , Virginie Rappeneau 2 , Onno C Meijer 3 , Chadi Touma 2 , Margarita Arango-Lievano 1 , Michael J Garabedian 4 , Freddy Jeanneteau 1
Affiliation  

Abstract

The diversity of actions of the glucocorticoid stress hormones among individuals and within organs, tissues and cells is shaped by age, gender, genetics, metabolism, and the quantity of exposure. However, such factors cannot explain the heterogeneity of responses in the brain within cells of the same lineage, or similar tissue environment, or in the same individual. Here, we argue that the stress response is continuously updated by synchronized neural activity on large-scale brain networks. This occurs at the molecular, cellular and behavioral levels by crosstalk communication between activity-dependent and glucocorticoid signaling pathways, which updates the diversity of responses based on prior experience. Such a Bayesian process determines adaptation to the demands of the body and external world. We propose a framework for understanding how the diversity of glucocorticoid actions throughout brain networks is essential for supporting optimal health, while its disruption may contribute to the pathophysiology of stress-related disorders, such as major depression, and resistance to therapeutic treatments.



中文翻译:

大规模脑网络应激反应过程中糖皮质激素受体的经验和活动依赖性控制

摘要

糖皮质激素应激激素在个体之间以及器官、组织和细胞内的作用的多样性受年龄、性别、遗传、新陈代谢和暴露量的影响。然而,这些因素无法解释同一谱系或类似组织环境或同一个体的细胞内大脑反应的异质性。在这里,我们认为压力反应是通过大规模大脑网络上的同步神经活动不断更新的。这发生在分子、细胞和行为水平,通过活动依赖性和糖皮质激素信号通路之间的串扰通信,根据先前的经验更新反应的多样性。这样的贝叶斯过程决定了对身体和外部世界需求的适应。

更新日期:2020-08-26
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