Transcatheter Aortic Valve Implantation (TAVI) has become today a popular alternative technique to surgical valve replacement for critical patients. However, with only six years follow up on average, little is known about the long-term durability of transcatheter implanted biological tissue. Moreover, the high cost of tissue harvesting and chemical treatment procedures favor the development of alternative synthetic valve leaflet materials. In that context, thin, strong and flexible woven fibrous constructions could be considered as interesting candidates. However, the interaction of textile material with living tissue should be comparable to biological tissue, and the Foreign Body Reaction (FBR) in particular should be controlled. Actually, the porosity of textile materials tends to induce exaggerated tissue ingrowth which may prevent the implants from remaining flexible. The purpose of this preliminary animal case study is to investigate the influence of the valve leaflet yarn orientation on the fibrotic tissue ingrowth. For that purpose the in vivo performances of 45° inclined yarn woven valve leaflets implanted in juvenile sheep model were assessed after three months implantation. Results bring out that in the frame of this case study the development of fibrosis is limited with a woven fabric valve obtained from 45° inclined yarns.

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纱线方向如何限制编织聚酯心脏瓣膜支架中的纤维化组织向内生长：病例报告

经导管主动脉瓣植入术 (TAVI) 已成为当今危重患者手术瓣膜置换术的流行替代技术。然而，平均只有六年的随访，对经导管植入生物组织的长期耐久性知之甚少。此外，组织采集和化学处理程序的高成本有利于替代合成瓣膜小叶材料的开发。在这种情况下，薄、坚固和灵活的编织纤维结构可以被认为是有趣的候选者。然而，纺织材料与活组织的相互作用应与生物组织相当，尤其应控制异物反应 (FBR)。实际上，纺织材料的孔隙率往往会导致过度的组织向内生长，这可能会阻止植入物保持柔韧性。本初步动物案例研究的目的是研究瓣叶纱线方向对纤维化组织向内生长的影响。为此目的，在植入三个月后评估了植入幼绵羊模型的 45° 倾斜纱线编织瓣膜小叶的体内性能。结果表明，在本案例研究的框架中，纤维化的发展受到从 45° 倾斜纱线获得的机织织物阀门的限制。为此目的，在植入三个月后评估了植入幼绵羊模型的 45° 倾斜纱线编织瓣膜小叶的体内性能。结果表明，在本案例研究的框架中，纤维化的发展受到从 45° 倾斜纱线获得的机织织物阀门的限制。为此目的，在植入三个月后评估了植入幼绵羊模型的 45° 倾斜纱线编织瓣膜小叶的体内性能。结果表明，在本案例研究的框架中，纤维化的发展受到从 45° 倾斜纱线获得的机织织物阀门的限制。