Background/objectives: The longitudinal effect of abdominal weight status (AWS) defined by waist circumference (WC) on healthy aging has not yet been comprehensively examined. Therefore, the purpose of the present study was to examine the temporal association between WC-defined AWS and a comprehensive assessment for healthy aging. Subjects/methods: This study utilized data from 5211 respondents aged 65+ who participated in the National Health and Aging Trends Study from 2011 to 2018. Mixed effects regression models were used to examine the association between baseline AWS and the annual change rate in healthy aging score (HAS) via interaction terms (AWS*round) adjusting for confounding effects. Further multiple mixed models examined the relationship of AWS and HAS over an 8-year period. Results: There were no annual change rate differences in HAS by baseline AWS, regardless of sex. However, males with abdominal obesity were more likely to have a lower HAS than males with normal AWS (β = −0.20, 95% CI: −0.30, −0.10, p < 0.001) but no difference in HAS was observed between males with overweight and normal AWS. A similar pattern was observed among females. Conclusions: Study results indicate that AWS was associated with HAS but it did not modify annual HAS change rate over time.

中文翻译：

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腹部体重状况与健康老龄化之间的时间关联：2011-2018年国家健康与老龄化趋势研究的发现。

背景/目的： 腰围（WC）定义的腹部体重状态（AWS）对健康衰老的纵向影响尚未得到全面研究。因此，本研究的目的是检查WC定义的AWS与健康衰老的综合评估之间的时间关联。主题/方法： 本研究使用了2011年至2018年参加“国家健康与衰老趋势研究”的5211位65岁以上受访者的数据。混合效应回归模型用于检验基线AWS与健康衰老的年变化率之间的关联互动条件（AWS * round）的得分（HAS）进行调整，以解决混杂问题。进一步的多种混合模型检查了8年期间AWS和HAS的关系。结果： 不论性别，按基线AWS进行的HAS年度变化率均无差异。但是，腹部肥胖的男性比正常AWS的男性更可能具有较低的HAS（β= -0.20，95％CI：-0.30，-0.10，p <0.001），但是体重超重的男性之间没有观察到HAS的差异和普通的AWS。在女性中观察到类似的模式。结论： 研究结果表明，AWS与HAS相关，但它并未随着时间改变HAS的年度变化率。