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Cryptotanshinone ameliorates the pathogenicity of Streptococcus suis by targeting suilysin and inflammation
Journal of Applied Microbiology ( IF 4 ) Pub Date : 2020-08-04 , DOI: 10.1111/jam.14810
Y Liu 1 , H Wang 1 , J Gao 1 , Z Wen 1 , L Peng 1
Affiliation  

Streptococcus suis is a highly zoonotic pathogen that is a serious threat to human health and the development of the pig industry worldwide. The virulence factors produced during S. suis infection play an important role, and the pore‐forming activity of suilysin is considered an important virulence‐related factor, especially in meningitis. Treatment of S. suis infection with traditional antibiotics is becoming increasingly challenging due to bacterial resistance. The purpose of this study is to verify the role of cryptotanshinone in the process of S. suis infection and provide a new drug precursor for the treatment of S. suis infection.

中文翻译:

隐丹参酮通过靶向suilysin和炎症改善猪链球菌的致病性

猪链球菌是一种高度人畜共患病的病原体,对人类健康和全球养猪业的发展均构成严重威胁。猪链球菌感染期间产生的毒力因子起重要作用,而水溶素的成孔活性被认为是重要的毒力相关因子,尤其是在脑膜炎中。由于细菌的耐药性,用传统抗生素治疗猪链球菌感染正变得越来越具有挑战性。这项研究的目的是验证隐在的过程中的作用猪链球菌感染,并提供用于治疗一种新的药物前体猪链球菌感染。
更新日期:2020-08-04
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