Over the last decades the use of antimicrobial regional limb perfusion (A‐RLP) has increased and A‐RLP is nowadays commonly used to treat orthopaedic infections by many equine practitioners. There have been a large number of studies published on the use of A‐RLP, many of which describe regional drug pharmacokinetics and clinical safety of the administration of different antimicrobials by A‐RLP. A limited number of studies describe the clinical use of A‐RLP as prophylactic or therapeutic treatment. However, despite being in use for 30 years there is still limited evidence about the efficacy of A‐RLP as a means to prevent and treat orthopaedic infections in horses.

中文翻译：

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抗菌剂局部肢体灌注：真的可以抵抗感染吗？

在过去的几十年中，使用抗菌剂局部肢体灌注（A-RLP）的情况有所增加，如今，A-RLP被许多马术医生普遍用于治疗骨科感染。关于A‐RLP的使用已经发表了大量研究，其中许多描述了A‐RLP施用不同抗菌药物的区域药物药代动力学和临床安全性。有限的研究将A‐RLP的临床用途描述为预防或治疗方法。然而，尽管已经使用了30年，但关于A‐RLP作为预防和治疗马匹骨科感染的手段的功效的证据仍然很少。