Altered organization of the transverse‐tubular network is an early pathological event occurring even prior to the onset of heart failure. Such t‐tubular remodelling disturbs the synchrony and signalling between membranous and intracellular ion channels, exchangers, receptors and ATPases essential in the dynamics of excitation‐contraction coupling, leading to ionic abnormality and mechanical dysfunction in heart disease progression. In this study, we investigated whether a disrupted t‐tubular network has a direct effect on cardiac mechano‐energetics. Our aim was to understand the fundamental link between t‐tubular remodelling and impaired energy metabolism, both of which are characteristics of heart failure. We thus studied healthy tissue preparations in which cellular processes are not altered by any disease event.

中文翻译：

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横管网络的破坏降低了心肌收缩的能量效率。

横管网络组织的改变是一种早期病理事件，甚至在心力衰竭发作之前就发生了。这种 t 管重塑扰乱了膜和细胞内离子通道、交换器、受体和 ATP 酶之间的同步和信号传导，这些在兴奋-收缩耦合动力学中至关重要，导致心脏病进展中的离子异常和机械功能障碍。在这项研究中，我们调查了被破坏的 t 管网络是否对心脏机械能学有直接影响。我们的目标是了解 t 管重塑与能量代谢受损之间的基本联系，这两者都是心力衰竭的特征。因此，我们研究了健康组织制剂，其中细胞过程不会因任何疾病事件而改变。