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Acinetobacter baumannii: Polymyxins Bind to the Cell Surface of Unculturable Acinetobacter baumannii and Cause Unique Dependent Resistance (Adv. Sci. 15/2020)
Advanced Science ( IF 15.1 ) Pub Date : 2020-08-05 , DOI: 10.1002/advs.202070082
Yan Zhu , Jing Lu , Mei‐Ling Han , Xukai Jiang , Mohammad A. K. Azad , Nitin A. Patil , Yu‐Wei Lin , Jinxin Zhao , Yang Hu , Heidi H. Yu , Ke Chen , John D. Boyce , Rhys A. Dunstan , Trevor Lithgow , Christopher K. Barlow , Weifeng Li , Elena K. Schneider‐Futschik , Jiping Wang , Bin Gong , Bjorn Sommer , Darren J. Creek , Jing Fu , Lushan Wang , Falk Schreiber , Tony Velkov , Jian Li

In article number 2000704, Jian Li and co‐workers elucidate the novel mechanism of dependent resistance to the last‐line polymyxins in a high‐priority “superbug” Acinetobacter baumannii . Polymyxindependent resistance cannot be detected by conventional microbiological diagnosis due to the lack of growth on normal agar plates. These polymyxin‐dependent Acinetobacter baumannii isolates utilize the rigid polymyxin molecules as sticking plasters to stabilize their fragile lipopolysaccharide‐deficient and phosphatidylglycerol‐rich outer membrane.
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中文翻译:

鲍曼不动杆菌:多粘菌素与不可培养的鲍曼不动杆菌的细胞表面结合并引起独特的依赖性耐药(Adv。Sci。15/2020)

李健和他的同事在文章2000704中阐明了高优先级“超级细菌”鲍曼不动杆菌对最后一线多粘菌素的依赖性抗性的新机制。由于正常琼脂平板上缺乏生长,常规微生物诊断无法检测到多粘菌素依赖性耐药。这些依赖于多粘菌素的鲍曼不动杆菌分离物利用刚性多粘菌素分子作为粘贴膏来稳定其易碎的脂多糖不足和富含磷脂酰甘油的外膜。
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更新日期:2020-08-05
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