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Profound regional spectral, connectivity and network changes reflect visual deficits in Posterior Cortical Atrophy: an EEG study
Neurobiology of Aging ( IF 4.2 ) Pub Date : 2020-12-01 , DOI: 10.1016/j.neurobiolaging.2020.07.029
Casper T Briels 1 , Jakoba J Eertink 2 , Cornelis J Stam 2 , Wiesje M van der Flier 3 , Philip Scheltens 4 , Alida A Gouw 2
Affiliation  

Patients with posterior cortical atrophy (PCA-AD) show more severe visuospatial and perceptual deficits than those with typical AD (tAD). The aim of this study was to investigate whether functional alterations measured by electroencephalography can help understand the mechanisms that explain this clinical heterogeneity. 21-channel electroencephalography recordings of 29 patients with PCA-AD were compared with 29 patients with tAD and 29 controls matched for age, gender, and disease severity. Patients with PCA-AD and tAD both showed a global decrease in fast and increase in slow oscillatory activity compared with controls. This pattern was, however, more profound in patients with PCA-AD which was driven by more extensive slowing of the posterior regions. Alpha band functional connectivity showed a similar decrease in PCA-AD and tAD. Compared with controls, a less integrated network topology was observed in PCA-AD, with a decrease of posterior and an increase of frontal hubness. In PCA-AD, decreased right parietal peak frequency correlated with worse performance on visual tasks. Regional vulnerability of the posterior network might explain the atypical pattern of neurodegeneration in PCA-AD.

中文翻译:

深刻的区域光谱、连通性和网络变化反映了后皮质萎缩的视觉缺陷:脑电图研究

后皮质萎缩 (PCA-AD) 患者比典型 AD (tAD) 患者表现出更严重的视觉空间和知觉缺陷。本研究的目的是调查通过脑电图测量的功能改变是否有助于理解解释这种临床异质性的机制。将 29 名 PCA-AD 患者的 21 通道脑电图记录与 29 名 tAD 患者和 29 名年龄、性别和疾病严重程度相匹配的对照进行了比较。与对照组相比,PCA-AD 和 tAD 患者均表现出快速振荡活动的整体减少和缓慢振荡活动的增加。然而,这种模式在 PCA-AD 患者中更为明显,这是由后部区域更广泛的减速驱动的。Alpha 波段功能连接显示 PCA-AD 和 tAD 类似的下降。与对照组相比,PCA-AD 中观察到的网络拓扑结构的集成度较低,后部的减少和前部的中心度增加。在 PCA-AD 中,右顶叶峰值频率降低与视觉任务表现较差相关。后网络的区域脆弱性可能解释了 PCA-AD 中神经变性的非典型模式。
更新日期:2020-12-01
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