A human biomonitoring project investigating environmental exposures to metals from hair, blood and urine samples was implemented in the Northwest Territories, Canada, between January 2016 and March 2018. This study reports the metal biomarker levels from nine Dene communities located in the Dehcho and Sahtú regions to identify contaminants of interest.

Levels of metals in the urine (n=198), blood (n=276) and hair (n=443) samples were generally similar to those seen in other biomonitoring studies in Canada, but lead levels in blood (GM = 16 μg/L; 95^th percentile = 71 μg/L) and urine (GM = 0.59 μg/L, 0.69 μg/g of creatinine; 95^th percentile = 4.2 μg/L, 4.0 μg/g of creatinine) were higher than those observed in the Canadian Health Measure Survey (CHMS, cycles 2 and 5). Hair mercury (but not blood mercury) appeared higher than observed in participants from the CHMS cycle 5. The vast majority of participants had biomarker levels below the biomonitoring guidance values established for mercury and lead. Based on a comparative analysis of biomarker statistics relative to a nationally-representative survey, metals and essential trace elements of particular interest for follow-up research include: lead, manganese, mercury, and selenium.

This project provided baseline biomarker levels in participating regions, which is essential to track changes in the future, and identify the contaminants to prioritize for further investigation of exposure determinants.

2016年1月至2018年3月，在加拿大西北地区实施了一项人类生物监测项目，研究头发，血液和尿液样本中金属与环境的接触。该研究报告了Dehcho和Sahtú地区9个Dene社区的金属生物标志物含量识别感兴趣的污染物。

尿液（n = 198），血液（n = 276）和头发（n = 443）样品中的金属水平通常与加拿大其他生物监测研究中所见的相似，但血液中的铅水平（GM = 16μg/ L，95^个百分位数= 71微克/升）和尿（GM = 0.59微克/升，0.69微克肌酸酐/克; 95^第百分位数= 4.2μg/ L，4.0μg/ g肌酐）高于加拿大健康测量调查（CHMS，第2和第5周期）中观察到的百分比。头发中的汞（而非血液中的汞）似乎比CHMS周期5中的参与者要高。绝大多数参与者的生物标志物含量均低于针对汞和铅建立的生物监测指导值。根据与国家代表调查有关的生物标志物统计数据的比较分析，特别值得关注的金属和微量元素包括：铅，锰，汞和硒。

该项目提供了参与地区的基线生物标志物水平，这对于跟踪未来的变化以及确定污染物以优先进行暴露决定因素的进一步研究至关重要。