The performance of an immunofluorescence-based Streptococcus pneumoniae antigen detection test in pleural fluid (IF-PF) was evaluated. For proven and possible pneumococcal pneumonias global sensitivity and specificity were 92.6 (95 CI 76.6–97.9) and 80 (95 CI 62.7–90.5), respectively, with no significant differences between children and adults. Global diagnostic accuracy of IF-PF was 86% (74.2–93.7), and a substantial k index of concordance with culture/RT-PCR of 0.716 (0.535–0.896). IF-PF might be useful as a rapid complementary test for the etiologic diagnosis of pneumococcal pneumonia.

中文翻译：

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胸膜液中肺炎链球菌抗原的检测：基于免疫荧光的侧向血流分析对肺炎球菌肺炎诊断的有用性。

评估了基于免疫荧光的胸水（IF-PF）中肺炎链球菌抗原检测测试的性能。对于已证实和可能的肺炎球菌性肺炎，全球敏感性和特异性分别为92.6（95 CI 76.6–97.9）和80（95 CI 62.7–90.5），儿童和成人之间无显着差异。IF-PF的全球诊断准确性为86％（74.2–93.7），与培养物/ RT-PCR的基本k指数为0.716（0.535–0.896）。IF-PF可能作为肺炎球菌性肺炎的病因诊断的快速补充检测有用。