During the last few years, much scientific effort has been devoted to the control of ionic transport properties of solid state nanochannels and the rational integration of chemical systems to induce changes in the ionic transport by interaction with selected target molecules for (bio)sensing purposes. In this work, we present the construction and functional evaluation of a highly sensitive dopamine-responsive iontronic device by functionalization of bullet-shaped track-etched single nanochannels in PET membranes with poly(3-aminobenzylamine) (PABA). The variety of basic groups in this amino-appended polyaniline derivative allows programming of the ion selectivity of the channel by setting the pH conditions. On the other hand, the amino-pendant groups of PABA become suitable binding sites for the selective chemical reaction with dopamine, leading to a change in the nanochannel surface charge. Thus, the exposure of the PABA-modified nanochannel to dopamine solutions selectively produces changes in the iontronic response. By rationally selecting the conditions for both the dopamine binding step and the iontronic reading, we obtained a correlation between the rectification efficiency and dopamine concentration down to the nanomolar range, which was also successfully interpreted in terms of a simple binding model.

中文翻译：

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通过用聚（3-氨基苄胺）衍生的仿生纳米流体二极管高灵敏度检测多巴胺。

在过去的几年中，已经进行了大量的科学努力来控制固态纳米通道的离子传输特性，以及化学系统的合理整合，以通过与（生物）传感目的的选定目标分子相互作用来诱导离子传输的变化。在这项工作中，我们通过用聚（3-氨基苄胺）（PABA）在PET膜上对子弹形轨迹蚀刻的单个纳米通道进行功能化，介绍了一种高灵敏度的多巴胺响应离子电子设备的构造和功能评估。该氨基附加的聚苯胺衍生物中的各种碱性基团允许通过设置pH条件来编程通道的离子选择性。另一方面，PABA的氨基侧基成为与多巴胺选择性化学反应的合适结合位点，导致纳米通道表面电荷的变化。因此，PABA修饰的纳米通道对多巴胺溶液的暴露选择性地产生了离子电子响应的变化。通过合理选择多巴胺结合步骤和电离电子读数的条件，我们获得了整流效率与低至纳摩尔范围内的多巴胺浓度之间的相关性，这也已通过简单的结合模型成功地得到了解释。