Background Mannose-binding lectin (MBL2) is considered to play a role in the human innate immune response to tuberculosis (TB) infections, and 4 common single nucleotide polymorphisms (SNPs) may be associated with pulmonary tuberculosis (PTB) risk. To examine these potential associations, we performed a comprehensive analysis to assess the relationships between MBL2 polymorphisms and PTB. Methods The PubMed, Embase, and SinoMed databases were searched for articles published prior to June 13, 2019. Odds ratios with 95% confidence intervals were calculated to evaluate the strength of the relationships. Results There were 37 case-control studies examining the effects of the four SNPs in MBL2 on PTB. A positive association between rs11003125 and PTB risk was observed in the hospital-based subgroup. Moreover, for the combined polymorphism and PTB risk, positive associations were detected not only in the total population but also in those with Asian origins across all source of control subgroups. No associations were found for rs7096206 or rs7095891. Conclusions Our current study indicated that several SNPs in MBL2 may be associated with susceptibility to PTB.

中文翻译：

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甘露糖结合凝集素2基因多态性与肺结核易感性的相关性

背景甘露糖结合凝集素 (MBL2) 被认为在人类对结核病 (TB) 感染的先天免疫反应中发挥作用，4 种常见的单核苷酸多态性 (SNP) 可能与肺结核 (PTB) 风险有关。为了检查这些潜在的关联，我们进行了综合分析以评估 MBL2 多态性和 PTB 之间的关系。方法 在 PubMed、Embase 和 SinoMed 数据库中搜索 2019 年 6 月 13 日之前发表的文章。计算具有 95% 置信区间的优势比以评估关系的强度。结果 有 37 项病例对照研究检查了 MBL2 中的四个 SNP 对 PTB 的影响。在基于医院的亚组中观察到 rs11003125 与 PTB 风险之间存在正相关。此外，对于组合多态性和 PTB 风险，不仅在总人口中，而且在所有控制亚组来源的亚裔人群中都检测到了正相关。未发现 rs7096206 或 rs7095891 的关联。结论 我们目前的研究表明 MBL2 中的几个 SNP 可能与对 PTB 的易感性有关。